Detrimental effect of obesity on lesions associated with Alzheimer's disease

Public release date: 7-Jan-2013
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Contact: Press Inserm
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)

In France, more than 860,000 people suffer from Alzheimer's disease and related disorders, making them the largest cause of age-related loss of intellectual function. Cognitive impairments observed in Alzheimer's disease result from the accumulation of abnormal tau proteins in nerve cells undergoing degeneration . We know that obesity, a major risk factor in the development of insulin resistance and type 2 diabetes, increases the risk of dementia during the aging process. However, the effects of obesity on 'Taupathies' (i.e. tau protein-related disorders), including Alzheimer's disease, were not clearly understood. In particular, researchers assumed that insulin resistance played a major role in terms of the effects of obesity.

The "Alzheimer & Tauopathies" team from mixed research unit 837 (Inserm/Universit Lille 2/Universit Lille Nord de France) directed by Dr. Luc Bue, in collaboration with mixed research unit 1011 "Nuclear receptors, cardiovascular diseases and diabetes", have just demonstrated, in mice, that obese subjects develop aggravated disorders. To achieve this result, young transgenic mice, who develop tau-related neurodegeneration progressively with age, were put on a high-fat diet for five months, leading to progressive obesity.

"At the end of this diet, the obese mice had developed an aggravated disorder both from the point of view of memory and modifications to the Tau protein" explains David Blum, in charge of research at Inserm.

This study uses a neurodenegeneration model of Alzheimer's disease to provide experimental evidence of the relationship between obesity and disorders linked to the tau protein. Furthermore, it indicates that insulin resistance is not the aggravating factor, as was suggested in previous studies.

"Our research supports the theory that environmental factors contribute massively to the development of this neurodegenerative disorder" underlines the researcher. "Our work is now focussing on identifying the factors responsible for this aggravation" he adds.

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This research was supported by LabEx DISTALZ (development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer's Disease) within the framework of future investments.

Sources

Detrimental Effects of Diet-Induced Obesity on ? Pathology Is Independent of Insulin Resistance in ? Transgenic Mice

Antoine Leboucher 1,2, Cyril Laurent1,2, Francisco-Jos Fernandez-Gomez 1,2, Sylvie Burnouf 1,2, Laetitia Troquier 1,2, Sabiha Eddarkaoui 1,2, Dominique Demeyer 1,2, Raphalle Caillierez 1,2, Nadge Zommer 1,2, Emmanuelle Vallez 1,3,4, Kadiombo Bantubungi 1,3,4, Christophe Breton 1,5, Pascal Pigny 1,2,6, Valrie Bue-Scherrer 1,2, Bart Staels 1,3,4, Malika Hamdane 1,2, Anne Tailleux 1,3,4, Luc Bue 1,2,6 and David Blum1,2,6

David Blum
Charg de recherche Inserm
david.blum@inserm.fr

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 7-Jan-2013
[ | E-mail | Share ]

Contact: Press Inserm
presse@inserm.fr
INSERM (Institut national de la sant et de la recherche mdicale)

In France, more than 860,000 people suffer from Alzheimer's disease and related disorders, making them the largest cause of age-related loss of intellectual function. Cognitive impairments observed in Alzheimer's disease result from the accumulation of abnormal tau proteins in nerve cells undergoing degeneration . We know that obesity, a major risk factor in the development of insulin resistance and type 2 diabetes, increases the risk of dementia during the aging process. However, the effects of obesity on 'Taupathies' (i.e. tau protein-related disorders), including Alzheimer's disease, were not clearly understood. In particular, researchers assumed that insulin resistance played a major role in terms of the effects of obesity.

The "Alzheimer & Tauopathies" team from mixed research unit 837 (Inserm/Universit Lille 2/Universit Lille Nord de France) directed by Dr. Luc Bue, in collaboration with mixed research unit 1011 "Nuclear receptors, cardiovascular diseases and diabetes", have just demonstrated, in mice, that obese subjects develop aggravated disorders. To achieve this result, young transgenic mice, who develop tau-related neurodegeneration progressively with age, were put on a high-fat diet for five months, leading to progressive obesity.

"At the end of this diet, the obese mice had developed an aggravated disorder both from the point of view of memory and modifications to the Tau protein" explains David Blum, in charge of research at Inserm.

This study uses a neurodenegeneration model of Alzheimer's disease to provide experimental evidence of the relationship between obesity and disorders linked to the tau protein. Furthermore, it indicates that insulin resistance is not the aggravating factor, as was suggested in previous studies.

"Our research supports the theory that environmental factors contribute massively to the development of this neurodegenerative disorder" underlines the researcher. "Our work is now focussing on identifying the factors responsible for this aggravation" he adds.

###

This research was supported by LabEx DISTALZ (development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer's Disease) within the framework of future investments.

Sources

Detrimental Effects of Diet-Induced Obesity on ? Pathology Is Independent of Insulin Resistance in ? Transgenic Mice

Antoine Leboucher 1,2, Cyril Laurent1,2, Francisco-Jos Fernandez-Gomez 1,2, Sylvie Burnouf 1,2, Laetitia Troquier 1,2, Sabiha Eddarkaoui 1,2, Dominique Demeyer 1,2, Raphalle Caillierez 1,2, Nadge Zommer 1,2, Emmanuelle Vallez 1,3,4, Kadiombo Bantubungi 1,3,4, Christophe Breton 1,5, Pascal Pigny 1,2,6, Valrie Bue-Scherrer 1,2, Bart Staels 1,3,4, Malika Hamdane 1,2, Anne Tailleux 1,3,4, Luc Bue 1,2,6 and David Blum1,2,6

David Blum
Charg de recherche Inserm
david.blum@inserm.fr

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-01/ind-deo010713.php

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NBC's 'Biggest Loser' is more timely than ever - On The Air on ...

When it comes to keeping a show relevant, NBC has all its ducks in a row with season fourteen of "The Biggest Loser."

Weight loss competish show from Shine America, which premieres tonight at 9 p.m., arrives less than one week into the new year, when diet and fitness resolutions are fresh on the minds of TV auds. And, per usual, the health spectrum in the consumer industry remains a powerhouse money-maker, with a new miracle diet book published practically every week and fitness crazes popping up in every major metropolitan city.

So, while timing plays to "Biggest Loser's" favor along with consumer interest, the real relevance of season fourteen lies in a format change that focuses on childhood obesity, a topic spearheaded most notably by Michelle Obama, who launched health campaign "Let's Move" last year. This "Biggest Loser" spotlight on childhood obesity is critical, as one third of Americans age 2-19 are overweight.

For the first time in the show's run, "Biggest Loser" will integrate tykes. Two kids and one teen -- Lindsay, Biingo and Sunny -- will join the adults at the ranch, though they will not live there nor will they partake in weigh-ins. Instead, they will be encouraged to lead a healthier lifestyle and take fitness tests to gauge their progress.

The return of uber-coach Jillian Michaels for season fourteen, then, is especially timely since Michaels herself battled obesity when she was young.

"I was about 50 pounds overweight at my heaviest," Michaels told journos at "Biggest Loser's" TCA panel. She got in shape when her mother introduced her to martial arts. "[Being overweight], it was soul-crushing. It is soul-crushing for any kid...It takes all the innocence and joy out of being a child."

Fellow trainer Bob Harper dubbed the kids of this season "the heroes of our show."

"You won't see them compete to be in the house," Harper explained. "It's about uplifting them and getting the parents involved. We really do believe it starts at home, and what better show than 'The Biggest Loser' to bring this topic into homes every week?"

Show's theme for its fourteenth cycle, beyond childhood obesity, is "Challenge America," which has led to the launch of Biggestloser.com where TV auds can partake in health challenges each week.?

Dr. Joanna Dolgoff, "Biggest Loser's" Child Obesity Expert/Pediatrician, is confident in the show's focus this year: "We're not going to sit back silently as our children literally eat themselves to death."

Check out a teaser of season fourteen of "The Biggest Loser" here:

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Source: http://weblogs.variety.com/on_the_air/2013/01/nbcs-biggest-loser-is-more-timely-than-ever.html

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Patrick Murphy Boosted By Fellow Democrats After Allen West Takedown

WPTV:

U.S. Rep. Patrick Murphy careened through underground catacombs connecting the Capitol complex Thursday, bumping into pockets of other wide-eyed freshmen lawmakers and seasoned members.

Read the whole story at WPTV

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Source: http://www.huffingtonpost.com/2013/01/06/patrick-murphy-allen-west_n_2422076.html

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Technical HQ - Community College Vocational & Trade School

The field 'News' represents the rate of change in some registration data that you in the ?t thirty days, in time with online degree programs has exchanged. A change in time when within two weeks after this at your school has become known, with online degree programs is exchanged.

100 percent means that all changes in the administration of your school, within two weeks, with online degree programs has exchanged and that the data on time online degree programs registered.
0 percent means that the changes in the administration of your school late online degree programs has exchanged and that the information within two weeks online degree programs registered.
You are required to make changes in the administration of your school within two weeks after it you have become known to online degree programs exchange. Example: You are writing a new student enrollment date to November 1, 2011. This information must be received by November 14, 2011 in online degree programs registered.

If the ?t thirty days no changes in the administration of your school and you have been so no data is exchanged online degree programs, then the 'News' empty. There is then no percentage. The dashboard does not account for the school. If you have a vacation because no data has been able to deliver, the percentage of current events.

The numbers in the dashboard can change daily. The percentage actuality is updated daily. So let the dashboard always see the most current state. It is possible that the numbers in the dashboard do not match those on the ?university overview. The ?university-overview ie only changed twice a week.



Log, identify and (reported) registration
Because a number of concepts are very similar and sometimes used interchangeably, we put them here again for you here, log, identify, register, registration message.

Sign In
Before a student is actually at your school, you can already register a student. The registration of a student is not required but may for example when parents have already indicated that the student at your school before the student is 4 years. This is done by the data of the students in your student administration ( ) to register. This information allows you to identify forward offering to online degree programs.

Identify
You can personally offer to online degree programs through a 'Request ID'. So we can check whether the citizen service number or education number, date of birth and gender of the student are correct. online degree programs compares it with the data already in the online degree programs or registered with the data in the Municipal Personal Records Database (GBA). You get any missing or incorrect information fed back.

Source: http://technicalcollegesonline.blogspot.com/2013/01/what-does-actuality-on-dashboard-field.html

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Some wounded veterans shine on 'Alive Day'

Christopher Lee / Getty Images Europe

Lt. Brad Snyder, blinded in Afghanistan after stepping on an IED, spent his first "Alive Day" winning gold at the 2012 Paralympic Games in London.

By Bill Briggs, NBC News contributor

One year to the day after Lt. Brad Snyder lost his vision to a bomb explosion in Afghanistan, he swam ferociously across a pool. Then he stood atop a podium at the London Paralympics, wore gold around his neck and beamed to the national anthem, savoring the moment but seeing none of it.?

Exactly eight years after Tammy Duckworth lost her legs to a rocket-propelled grenade in Iraq, she met the Army medic who revived her inside a mangled helicopter. Amid that reunion, she had an extra reason to smile: Six days before, Duckworth had won a seat in the U.S. Congress.

During the otherwise dark anniversaries of their devastating combat injuries, both veterans chose to cherish the warm light of survival on what has come to be known, throughout the military, as ?Alive Day.?

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Their numbers are growing more slowly though still rising: Seventy American service members were wounded in Afghanistan during December, according to new Department of Defense figures. That made 2012 the third-bloodiest year of that war in terms of the tally of U.S. troops hurt in action ??2,951.

?Choice ??that word means a lot here,? said Snyder, 28, a former Navy bomb-disposal expert. ??Choice? puts everything on a level playing field. Each of us faces?a plethora of daily choices ??when to get up, what to eat for breakfast, what to say to your family before leaving for work. You can choose to be positive. Or you can choose to be a victim.

?You can choose to move forward with grace. Or you can choose to succumb to negativity.?

How Snyder capped his initial Alive Day made some people cry, including his mother who watched from poolside. It made thousands more cheer at London?s Olympic Aquatics Centre. Twelve months after stepping on an IED, he dove blindly into water for the 400-meter freestyle Paralympics final. He won by nearly six seconds ??an eternity in competitive racing.

Lt. Brad Snyder lost his sight in an IED explosion in Afghanistan in 2011. In September, the Navy officer once again represented the U.S., this time at the London 2012 Paralympics.

?Every (survivor of severe combat wounds) flirts potentially with a much more dismal outcome,? said Snyder, one of more than 50,000 U.S. troops wounded in Iraq and Afghanistan.??To be in a situation where you can still do something great, that?s the way I look at Alive Day.?

But the concept isn?t an easy mental fit for every disabled veteran, admitted Snyder, who lives in Baltimore and who will remain a Naval officer for a while longer. During a recent public-speaking event, he chatted with former service members and discovered that ?some of them just don?t even acknowledge Alive Day exists. Some look at this as a day when they only wear black, mope around and think about how miserable they want to be.?

The notion of trying to transform the anniversary of a nearly-fatal battle injury into an annual day of triumph was hatched before the Vietnam War, said Dr. Sydney Savion, a retired military officer, applied behavioral scientist and author of ?Camouflage to Pinstripes: Learning to Thrive in Civilian Culture.? She is based in Texas.

Alive Day, Savion said, is ?on some level, mind over matter." But she believes the concept serves as an effective mental-health salve and can be part of a path to lasting recovery.

?One of the most important things a veteran can learn to do in life is to reframe negative events that have happened to them. This is not to deny the close escape from death or the permanent wounds, sanitize them or hide them,? Savion said. ?Instead, look at them like creating a piece of art. Michaelangelo once said, ?I saw the angel in the marble and carved until I set it free.? Even the ugliest events, when looked at with fresh eyes, (can carry) newfound meaning, opportunities and answers.?

Many veterans try, through reunions, phone calls, emails and letters, to retain the tight camaraderie they formed with their unit buddies.?Alive Day, Savion added, offers another way ?to rekindle that connection.??

?If things are going to turn out well for any veteran, one thing (that) is paramount is redefining who one is and repurposing one?s life,? she said. ?One must mentally and emotionally surrender the old situation and experiment with new ways of being, doing, (and) thinking.?

Duckworth, a former Army chopper pilot, this week took that advice to Capitol Hill. In her second bid for Congress, she won a seat in the U.S. House of Representatives on Nov. 6, serving the suburbs north of Chicago. She was sworn in Thursday.

Getty Images

Newly elected Congressional freshmen Tammy Duckworth, D-Ill., arrives to pose for a class picture with other new members of the 113th Congress on the steps of the U.S. Capitol on Nov. 15, 2012, in Washington D.C.

The Monday after her election victory ??her most recent Alive Day???Duckworth met the man who pulled her back to consciousness after she and her co-pilot managed to land their damaged, smoking Black Hawk helicopter in 2004.

?I don?t remember being in the ER. I just met the flight medic who revived me in the helicopter. We just spent Alive Day together,? Duckworth told NBC News in?a recent interview. ?He said, ?You looked up at me. You were completely calm.? ?

Duckworth often spends her Alive Day with the five men who were aboard the chopper with her in 2004 as they skimmed treetops in Iraq at about 135 miles per hour. The group has sometimes gathered in St. Louis. She sees that anniversary, she said, as a ?celebration? ??and a moment when she can show appreciation to those who helped save her life.

But Alive Day also provides veterans with a unique bond, she added. After a photo shoot of Congressional freshmen snapped last November, Duckworth met a new lawmaker from California, Paul Cook, who was wounded in Vietnam.

?There?s a subset of us who have seen combat action,? Duckworth said. ?That?s the reason I was able to talk to this man. He started talking about walking into a trip wire in Vietnam and wanted to know what hit me, what that was like.??When you?ve actually not just been deployed, when you?ve both seen combat action, you have this common place.?

Duckworth?s 2013 Alive Day likely will be spent in the House of Representatives. It falls on a Tuesday.

Snyder?s 2013 Alive Day comes on a Saturday. He has resolved to ?raise the bar? on the feat he pulled off last Sept. 7. But he knows that will not be easy.

?I want to do something that?s more outstanding or more ridiculous,? Snyder said. ?Maybe I?ll climb a mountain or jump out of an aircraft. We?ll see. Certainly, it will be a day about moving forward. I?ll try to make the most of the fact that I?m still here. I?ll enjoy life to its fullest. That?s something I try to do every day ??but especially on that day.?

Archival video: Lt. Brad Snyder, blinded by an IED explosion in Afghanistan, is now training for the London 2012 Paralympics.

More content from NBCNews.com:

Follow US news from NBCNews.com on?Twitter?and?Facebook

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Source: http://usnews.nbcnews.com/_news/2013/01/05/16352368-some-wounded-vets-shine-on-alive-day-others-wear-black?lite

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Three killed as small plane crashes into Florida home

DEAR ABBY: I'm the youngest of three children and I'll be graduating from high school in the spring. My parents always seemed happy with each other. They were obviously in love, and they told my brothers and me they would never get divorced. Although they had arguments, they always made up, and it never seemed to be serious.For the last few months, my dad has been acting weird. He spends a lot of time talking to and texting "a friend" on the phone. The problem is, although the friend has a male name ("George") in his contacts, the person has a female voice. ...

Source: http://news.yahoo.com/three-killed-small-plane-crashes-florida-home-231345975.html

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Bloomberg: Media need to rethink gun violence coverage

NEW YORK?New York City Mayor Michael Bloomberg said the media need to improve their coverage of gun violence, arguing the press pays attention to gun-related deaths only after mass shootings.

In an interview with NBC?s Jimmy Fallon, Bloomberg called the Dec. 14 shooting that killed 26 people at Sandy Hook Elementary School in Newtown, Conn., ?terribly tragic,? but said there is scant coverage of people who are killed by guns every day.

?This was a crazy person with an assault weapon,? Bloomberg said of the Sandy Hook shooting. ?But there?s 33 people killed in America with guns every single day of the year. And nobody seems to care. It only catches the press?s attention when it?s young kids concentrated. And it was terribly tragic, but there are kids killed every day all across this country.?

Bloomberg has emerged as one of the most vocal advocates of new gun-control measures since the Sandy Hook shooting, urging President Barack Obama to make the issue a top priority in his second term. But the mayor insisted he?s not trying to ban guns, telling Fallon that ?if you are responsible and you are adult and you don?t have a criminal record, there?s nothing wrong with you having a gun.?

The problem, Bloomberg said, is that Congress doesn?t ?fund enforcement? of existing gun laws and ?guns are getting into the hands of the wrong people.?

?There?s just too many guns in the world and certainly in this country,? Bloomberg said. ?And we?ve just got to do something about it.?

The mayor discussed his meeting Wednesday with former Arizona Rep. Gabrielle Giffords, who was shot at point-blank range and nearly killed during a constituent meeting two years ago. Giffords, who is set to visit Newtown today, resigned from Congress to focus on recovery.

?She's still recovering. She?s still doing therapy and yoga and struggling to learn to speak again. ? And she?s lucky. She lived,? Bloomberg said.

Source: http://news.yahoo.com/blogs/ticket/bloomberg-media-falls-short-covering-gun-violence-151547970--politics.html

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